Regeneration of descending axon tracts after spinal cord injury

被引：95

作者：

Deumens, R ^{[1
]}

Koopmans, GC

Joosten, EAJ

机构：

[1] Univ Maastricht, European Grad Sch Neurosci, EURON, Div Neurosci,Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[2] Acad Hosp Maastricht, Dept Anesthesiol, Maastricht, Netherlands

来源：

PROGRESS IN NEUROBIOLOGY | 2005年 / 77卷 / 1-2期

关键词：

spinal cord injury; axon tracts; regeneration;

D O I：

10.1016/j.pneurobio.2005.10.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Axons within the adult mammalian central nervous system do not regenerate spontaneously after injury. Upon injury, the balance between growth promoting and growth inhibitory factors in the central nervous system dramatically changes resulting in the absence of regeneration. Axonal responses to injury vary considerably. In central nervous system regeneration studies, the spinal cord has received a lot of attention because of its relatively easy accessibility and its clinical relevance. The present review discusses the axon-tract-specific requirements for regeneration in the rat. This knowledge is very important for the development and optimalization of therapies to repair the injured spinal cord. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：57 / 89

页数：33

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