Antifungal activity of chalcones: A mechanistic study using various yeast strains

被引：314

作者：

Lahtchev, K. L. ^{[2
]}

Batovska, D. I. ^{[1
]}

Parushev, St P. ^{[1
]}

Ubiyvovk, V. M. ^{[3
]}

Sibirny, A. A. ^{[3
]}

机构：

[1] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, BU-1113 Sofia, Bulgaria

[3] Natl Acad Sci Ukraine, Inst Cell Biol, UA-79005 Lvov, Ukraine

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 43卷 / 10期

关键词：

Chalcones; Yeasts; Antifungal activity; Substituent effects;

D O I：

10.1016/j.ejmech.2007.12.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

We reported the synthesis, antifungal evaluation and study on substituent effects of 21 chalcones. A lot of genetically defined strains belonging to different yeast genera and species, namely Saccharomyces cerevisiae, Hansenula polymorpha and Kluyveromyces lactis, were used as test organisms. Concerning the mode of the antifungal action of chalcones it was shown that DNA was probably not the main target for the chalcones. It was revealed that the yeast's intracellular glutathione and cysteine molecules play significant role as defence barrier against the chalcone action. It was also shown that chalcones may react with some proteins involved in cell separation. (C) 2008 Elsevier Masson SAS. All fights reserved.

引用

页码：2220 / 2228

页数：9

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