Synthesis of benzylideneacetophenones and their inhibition of lipid peroxidation

被引：72

作者：

Arty, IS

Timmerman, H

Samhoedi, M

Sastrohamidjojo

Sugiyanto

van der Goot, H

机构：

[1] Vrije Univ Amsterdam, Dept Pharmacochem, Div Med Chem, Leiden Amsterdam Ctr Drug Res, NL-1081 HV Amsterdam, Netherlands

[2] FPMIPA IKIP Yogyakarta, Yogyakarta, Indonesia

[3] Gadjah Mada Univ, Fac Pharm, Yogyakarta, Indonesia

[4] Gadjah Mada Univ, FMIPA, Yogyakarta, Indonesia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2000年 / 35卷 / 04期

关键词：

benzylideneacetophenones; chalcones; lipid peroxidation; antioxidant;

D O I：

10.1016/S0223-5234(00)00137-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found in para hydroxy derivatives with two meta tert-butyl substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：449 / 457

页数：9

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