Hematopoiesis and stem cells:: plasticity versus developmental heterogeneity

被引：197

作者：

Orkin, SH ^{[1
]}

Zon, LI

机构：

[1] Dana Farber Canc Inst, Div Hematol & Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Dept Pediat, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 04期

关键词：

D O I：

10.1038/ni0402-323

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematopoietic stem cells (HSCs) provide for blood formation throughout the life of the individual. Studies of HSCs form a conceptual framework for the analysis of stem cells of other organ systems. We review here the origin of HSCs during embryological development, the relationship between hematopoiesis and vascular development and the potential plasticity of HSCs and other tissue stem cells. Recent experiments in the mouse have been widely interpreted as evidence for unprecedented transdifferentiation of tissue stem cells. The use of enriched, but impure, cell populations allows for alternative interpretation. In considering these findings, we draw a distinction here between the plasticity of adult stem cells and the heterogeneity of stem cell types that pre-exist within tissues.

引用

页码：323 / 328

页数：6

共 71 条

[41] In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos [J].

Nishikawa, S ;

Kawamoto, H ;

Yoshida, H ;

Kizumoto, M ;

Kataoka, H ;

Katsura, Y .

IMMUNITY, 1998, 8 (06) :761-769

[42]

North T, 1999, DEVELOPMENT, V126, P2563

[43] Diversification of haematopoietic stem cells to specific lineages [J].

Orkin, SH .

NATURE REVIEWS GENETICS, 2000, 1 (01) :57-64

[44] Stem cell alchemy [J].

Orkin, SH .

NATURE MEDICINE, 2000, 6 (11) :1212-1213

[45] Development of the hematopoietic system [J].

Orkin, SH .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (05) :597-602

[46] Mobilized bone marrow cells repair the infarcted heart, improving function and survival [J].

Orlic, D ;

Kajstura, J ;

Chimenti, S ;

Limana, F ;

Jakoniuk, I ;

Quaini, F ;

Nadal-Ginard, B ;

Bodine, DM ;

Leri, A ;

Anversa, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) :10344-10349

[47]

Orlic D, 2001, ANN NY ACAD SCI, V938, P221

[48] Bone marrow cells regenerate infarcted myocardium [J].

Orlic, D ;

Kajstura, J ;

Chimenti, S ;

Jakoniuk, I ;

Anderson, SM ;

Li, BS ;

Pickel, J ;

McKay, R ;

Nadal-Ginard, B ;

Bodine, DM ;

Leri, A ;

Anversa, P .

NATURE, 2001, 410 (6829) :701-705

[49] Molecular pathways in bone marrow homing:: dominant role of α4β1 over β2-integrins and selectins [J].

Papayannopoulou, T ;

Priestley, GV ;

Nakamoto, B ;

Zafiropoulos, V ;

Scott, LM .

BLOOD, 2001, 98 (08) :2403-2411

[50]

Pardanaud L, 1999, DEVELOPMENT, V126, P617

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