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Development of the zebrafish inner ear

被引：194
作者：
Whitfield, TT
Riley, BB
Chiang, MY
Phillips, B
机构：
[1] Univ Sheffield, Sch Med & Biomed Sci, Ctr Dev Genet, Sheffield S10 2TN, S Yorkshire, England
[2] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA
来源：
DEVELOPMENTAL DYNAMICS | 2002年 / 223卷 / 04期
关键词：
zebrafish; ear; otic placode; otic vesicle; statoacoustic ganglion; lateral line; hair cell; supporting cell; hearing; balance; auditory; vestibular; cell death; retinoic acid; BMP; Claudins; Dach; Delta-Notch; Eya1; FGF; Krml1; MyoVIIa; Nkx5.1; Pax2/5/8; Pou2; Raldh2; Sox10; Ugdh; Wnt; acerebellar; colourless; dog-eared; jekyll; mariner; mind bomb; monolith; neckless; no fin; no isthmus; one-eyed pinhead; spiel ohne grenzen; sputnik; valentino; van gogh; deafness;
D O I：
10.1002/dvdy.10073
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Recent years have seen a renaissance of investigation into the mechanisms of inner ear development. Genetic analysis of zebrafish has contributed significantly to this endeavour, with several dramatic advances reported over the past year or two. Here, we review the major findings from recent work in zebrafish. Several cellular and molecular mechanisms have been elucidated, including the signaling pathways controlling induction of the otic placode, morphogenesis and patterning of the otic vesicle, and elaboration of functional attributes of inner ear. (C) 2002 Wiley-Liss, Inc.
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页码：427 / 458
页数：32
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