Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

被引：43

作者：

Adamska, M

Léger, S

Brand, M

Hadrys, T

Braun, T

Bober, E

机构：

[1] Univ Halle Wittenberg, Inst Physiol Chem, D-06097 Halle, Germany

[2] Tech Univ Braunschweig, Dept Cellular & Mol Biol, D-38106 Braunschweig, Germany

[3] Univ Heidelberg, Dept Neurobiol, D-69120 Heidelberg, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 97卷 / 1-2期

关键词：

homeobox; Nkx genes; FGF8; inner ear; lateral line; zebrafish;

D O I：

10.1016/S0925-4773(00)00414-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibule-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibule-acoustic ganglion. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：161 / 165

页数：5

共 17 条

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