Saccharomyces cerevisiae UFMG A-905 treatment reduces intestinal damage in a murine model of irinotecan-induced mucositis

被引:52
作者
Bastos, R. W. [1 ]
Pedroso, S. H. S. P. [1 ]
Vieira, A. T. [1 ]
Moreira, L. M. C. [1 ]
Franca, C. S. [1 ]
Cartelle, C. T. [2 ]
Arantes, R. M. E. [2 ]
Generoso, S. V. [3 ]
Cardoso, V. N. [4 ]
Neves, M. J. [5 ]
Nicoli, J. R. [1 ]
Martins, F. S. [1 ]
机构
[1] Univ Fed Minas Gerais, Dept Microbiol, Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Dept Gen Pathol, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Sch Nursing, Dept Basic Nursing, Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Dept Clin & Toxicol Anal, Fac Pharm, Belo Horizonte, MG, Brazil
[5] CNEN, CDTN, Brazilian Nucl Energy Commiss, Ctr Nucl Technol Dev, Belo Horizonte, MG, Brazil
关键词
probiotic; Saccharomyces cerevisiae UFMG A-905; chemotherapy; mucositis; oxidative stress; GASTROINTESTINAL-TRACT; OXIDATIVE STRESS; INDUCED DIARRHEA; CLINICAL-TRIAL; IMMUNE-SYSTEM; TOXICITY; TRANSLOCATION; PROBIOTICS; BOULARDII; MICROFLORA;
D O I
10.3920/BM2015.0190
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学];
摘要
Indigenous microbiota plays a crucial role in the development of several intestinal diseases, including mucositis. Gastrointestinal mucositis is a major and serious side effect of cancer therapy, and there is no effective therapy for this clinical condition. However, some probiotics have been shown to attenuate such conditions. To evaluate the effects of Saccharomyces cerevisiae UFMG A-905 (Sc-905), a potential probiotic yeast, we investigated whether pre-or post-treatment with viable or inactivated Sc-905 could prevent weight loss and intestinal lesions, and maintain integrity of the mucosal barrier in a mucositis model induced by irinotecan in mice. Only post-treatment with viable Sc-905 was able to protect mice against the damage caused by chemotherapy, reducing the weight loss, increase of intestinal permeability and jejunal lesions (villous shortening). Besides, this treatment reduced oxidative stress, prevented the decrease of goblet cells and stimulated the replication of cells in the intestinal crypts of mice with experimental mucositis. In conclusion, Sc-905 protects animals against irinotecan-induced mucositis when administered as a post-treatment with viable cells, and this effect seems to be related with the reduction of oxidative stress and preservation of intestinal mucosa.
引用
收藏
页码:549 / 558
页数:10
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