Intracellular pathways involved in tumor necrosis factor-alpha release by human monocytes on stimulation with lipopolysaccharide or staphylococcal peptidoglycan are partly similar

被引:41
作者
Mattsson, E
VanDijk, H
VanKessel, K
Verhoef, J
Fleer, A
机构
[1] UNIV UTRECHT, EIJKMAN WINKLER INST MED MICROBIOL, UTRECHT, NETHERLANDS
[2] UNIV UTRECHT, DEPT PHARMACOGNOSY, UTRECHT, NETHERLANDS
[3] LUND UNIV, DEPT INFECT DIS, S-22100 LUND, SWEDEN
关键词
D O I
10.1093/infdis/173.1.212
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study compared the effects of intracellular pathway inhibitors on tumor necrosis factor-alpha (TNF-alpha) release from human monocytes, Cells were stimulated with peptidoglycan (PG) from Staphylococcus epidermidis or with Escherichia coli lipopolysaccharide (LPS), both in the presence of 10% human serum. Of 10 substances tested, only the protein tyrosine kinase inhibitor tyrphostin AG 126 discriminated significantly between PG and LPS: TNF-alpha release induced by PG, but not by LPS, was dose-dependently suppressed. The results obtained with other modulatory substances, including different protein kinase and G protein inhibitors, suggest that calmodulin-dependent protein kinase, protein tyrosine kinase, and a cholera-toxin-sensitive G protein are involved in both PG- and LPS-induced TNF-alpha release. Further, drugs such as pentoxifylline, chloroquine, and the antioxidant apocynin similarly inhibited TNF-alpha release by PG- as well as LPS-stimulated cells.
引用
收藏
页码:212 / 218
页数:7
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