Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma

被引：76

作者：

Amodio, Nicola ^{[1
,2
]}

Di Martino, Maria Teresa ^{[1
,2
]}

Neri, Antonino ^{[3
]}

Tagliaferri, Pierosandro ^{[1
,2
]}

Tassone, Pierfrancesco ^{[1
,2
,4
]}

机构：

[1] Magna Graecia Univ Catanzaro, I-88100 Catanzaro, Italy

[2] T Campanella Canc Ctr, Dept Expt & Clin Med, Med Oncol Unit, I-88100 Catanzaro, Italy

[3] Univ Milan, Dept Clin Sci & Community Hlth, IRCCS Policlin Fdn, Milan, Italy

[4] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2013年 / 13卷

关键词：

microRNA; miRNA; miRNA therapeutics; multiple myeloma; non coding RNA; BORTEZOMIB-INDUCED APOPTOSIS; SUPER-ANTAGONIST SANT7; IN-VIVO MODEL; SMALL NUCLEOLAR; MICRORNA EXPRESSION; ALLELIC IMBALANCES; ANTITUMOR-ACTIVITY; DOWN-REGULATION; CELL-ADHESION; CANCER;

D O I：

10.1517/14712598.2013.796356

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Introduction: Increasing evidence indicates that non-coding RNAs (ncRNAs) are aberrantly expressed and/or functionally deregulated in hematological malignancies, including multiple myeloma. Harnessing these abnormalities by either replacing or inhibiting ncRNAs is emerging as novel therapeutic option. Areas covered: We review the recent remarkable advancement in the understanding of the biological functions of human ncRNAs in multiple myeloma, including the biogenesis, the mechanisms of expression, the relevance as biomarkers, and mostly, the therapeutic potential. Special emphasis is given to microRNAs, the best characterized class of ncRNAs. Expert opinion: An improved understanding of the role of ncRNAs in multiple myeloma would provide valuable information about key cancer-promoting pathways and might be highly useful for diagnostic and prognostic assessments. This knowledge might also lead to advancement in the management of multiple myeloma through the development of novel personalized ncRNA-based therapies.

引用

页码：S125 / S137

页数：13

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