Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode

被引：210

作者：

Rahuel, J ^{[1
]}

Gay, B ^{[1
]}

Erdmann, D ^{[1
]}

Strauss, A ^{[1
]}

GarciaEcheverria, C ^{[1
]}

Furet, P ^{[1
]}

Caravatti, G ^{[1
]}

Fretz, H ^{[1
]}

Schoepfer, J ^{[1
]}

Grutter, MG ^{[1
]}

机构：

[1] CIBA GEIGY AG, DIV PHARMACEUT, CH-4002 BASEL, SWITZERLAND

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 07期

关键词：

D O I：

10.1038/nsb0796-586

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complex of Grb2-SH2 a BCR-Abl target peptide reveals that the peptide binds in a p-turn conformation; Trp 121 closes the binding site C-terminal to the phosphotyrosyl residue of the ligand and prevents it from assuming the expected extended conformation.

引用

页码：586 / 589

页数：4

共 37 条

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