THE GRB2 ADAPTER

被引：133

作者：

CHARDIN, P ^{[1
]}

CUSSAC, D ^{[1
]}

MAIGNAN, SB ^{[1
]}

DUCRUIX, A ^{[1
]}

机构：

[1] CNRS, STRUCT BIOL LAB, F-91198 GIF SUR YVETTE, FRANCE

来源：

FEBS LETTERS | 1995年 / 369卷 / 01期

关键词：

GRB2; RAS; SH2; DOMAIN; SH3; SOS; TYROSINE KINASE;

D O I：

10.1016/0014-5793(95)00578-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Grb2 is an 'adaptor' protein made of one SH2 and two SH3 domains, The SH3 domains bind to prolinerich motifs in the C-terminal part of the ras exchange factor Sos. Binding of the Grb2 SH2 domain to phosphotyrosine motifs on receptors, or other adaptor proteins such as Shc, recruits this Grb2/Sos complex at the plasma membrane where Sos stimulates nucleotide exchange on ras, then ras activates raf and leads to MAP kinase activation. The structure of Grb2, the precise motifs recognised by its SH2 and SH3 domains, the way Grb2 performs its function, a possible regulation of its association with Sos, and its ability to complex with other proteins in vivo, are discussed.

引用

页码：47 / 51

页数：5

共 55 条

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