THE GRB2/SEM-5 ADAPTER PROTEIN

被引：173

作者：

DOWNWARD, J

机构：

[1] Imperial Cancer Research Fund, London, WC2A 3PX

来源：

FEBS LETTERS | 1994年 / 338卷 / 02期

关键词：

SIGNAL TRANSDUCTION; ADAPTER PROTEIN; RECEPTOR BINDING; SH2 AND SH3 DOMAINS; ACTIVATION OF RAS;

D O I：

10.1016/0014-5793(94)80346-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

GRB2/Sem-5 is a 25-kDa adaptor protein which contains a central Src homology type 2 (SH2) domain flanked by two Src homology type 3 (SH3) domains. GRB2/Sem-5 was first identified due to the essential role of the sem-5 gene product in the vulval induction pathway in Caenorhabditis elegans. The SH2 domain of GRB2/Sem-5 binds to a number of tyrosine phosphorylated proteins, most notably the epidermal growth factor receptor, the insulin receptor substrate IRS-1 and another putative adaptor protein, Shc. The SH3 domains bind to Sos, a guanine nucleotide exchange factor for Ras proteins. GRB2/Sem-5 brings together Sos and tyrosine phosphoproteins into a complex and thereby may regulate the nucleotide exchange rate of Ras and hence its activation state.

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页码：113 / 117

页数：5

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共 38 条

[1] THE LET-23 GENE NECESSARY FOR CAENORHABDITIS-ELEGANS VULVAR INDUCTION ENCODES A TYROSINE KINASE OF THE EGF RECEPTOR SUBFAMILY [J].

AROIAN, RV ;

KOGA, M ;

MENDEL, JE ;

OHSHIMA, Y ;

STERNBERG, PW .

NATURE, 1990, 348 (6303) :693-699

[2] BINDING OF THE RAS ACTIVATOR SON OF SEVENLESS TO INSULIN-RECEPTOR SUBSTRATE-1 SIGNALING COMPLEXES [J].

BALTENSPERGER, K ;

KOZMA, LM ;

CHERNIACK, AD ;

KLARLUND, JK ;

CHAWLA, A ;

BANERJEE, U ;

CZECH, MP .

SCIENCE, 1993, 260 (5116) :1950-1952

[3] SH3 DOMAINS DIRECT CELLULAR-LOCALIZATION OF SIGNALING MOLECULES [J].

BARSAGI, D ;

ROTIN, D ;

BATZER, A ;

MANDIYAN, V ;

SCHLESSINGER, J .

CELL, 1993, 74 (01) :83-91

[4] CAENORHABDITIS-ELEGANS RAS GENE LET-60 ACTS AS A SWITCH IN THE PATHWAY OF VULVAR INDUCTION [J].

BEITEL, GJ ;

CLARK, SG ;

HORVITZ, HR .

NATURE, 1990, 348 (6301) :503-509

[5] IDENTIFICATION OF MURINE HOMOLOGS OF THE DROSOPHILA SON OF SEVENLESS GENE - POTENTIAL ACTIVATORS OF RAS [J].

BOWTELL, D ;

FU, P ;

SIMON, M ;

SENIOR, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (14) :6511-6515

[6] EPIDERMAL GROWTH-FACTOR REGULATES THE EXCHANGE-RATE OF GUANINE-NUCLEOTIDES ON P21RAS IN FIBROBLASTS [J].

BUDAY, L ;

DOWNWARD, J .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1903-1910

[7] EPIDERMAL GROWTH-FACTOR REGULATES P21(RAS) THROUGH THE FORMATION OF A COMPLEX OF RECEPTOR, GRB2 ADAPTER PROTEIN, AND SOS NUCLEOTIDE EXCHANGE FACTOR [J].

BUDAY, L ;

DOWNWARD, J .

CELL, 1993, 73 (03) :611-620

[8] HUMAN SOS1 - A GUANINE-NUCLEOTIDE EXCHANGE FACTOR FOR RAS THAT BINDS TO GRB2 [J].

CHARDIN, P ;

CAMONIS, JH ;

GALE, NW ;

VANAELST, L ;

SCHLESSINGER, J ;

WIGLER, MH ;

BARSAGI, D .

SCIENCE, 1993, 260 (5112) :1338-1343

[9] C-ELEGANS CELL-SIGNALING GENE SEM-5 ENCODES A PROTEIN WITH SH2 AND SH3 DOMAINS [J].

CLARK, SG ;

STERN, MJ ;

HORVITZ, HR .

NATURE, 1992, 356 (6367) :340-344

[10] REGULATORY MECHANISMS FOR RAS PROTEINS [J].

DOWNWARD, J .

BIOESSAYS, 1992, 14 (03) :177-184

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