Target directed enediyne prodrugs: Cytotoxic estrogen conjugates

被引：26

作者：

Jones, GB ^{[1
]}

Huber, RS ^{[1
]}

Mathews, JE ^{[1
]}

Li, AW ^{[1
]}

机构：

[1] CLEMSON UNIV,BIOMED COOPERAT,GREENVILLE HOSP SYST,CLEMSON,SC 29634

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 21期

关键词：

D O I：

10.1016/0040-4039(96)00662-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enediyne estrogen conjugates have been prepared from readily available precursors. Enediyne 12 causes significant DNA strand scission at 10(-3) M, and has demonstrated cytotoxicity against the ER rich MCF-7 human breast cancer cell line. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：3643 / 3646

页数：4

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