TOWARDS ENEDIYNE LIBRARIES - CYCLIC ENEDIYNES VIA AN INTRAMOLECULAR CARBENOID COUPLING PROTOCOL

被引:32
作者
JONES, GB
HUBER, RS
MATHEWS, JE
机构
关键词
D O I
10.1039/c39950001791
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Functionalised bioactive enediynes can be produced- via an intramolecular carbenoid coupling of bis-prop-2-ynylic halides, and elaborated into useful synthons via their dicobalt hexacarbonyl complexes.
引用
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页码:1791 / 1792
页数:2
相关论文
共 14 条
[1]   CDPI3-ENEDIYNE AND CDPI3-EDTA CONJUGATES - A NEW CLASS OF DNA CLEAVING AGENTS [J].
BOGER, DL ;
ZHOU, JC .
JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (11) :3018-3024
[2]   TOTAL SYNTHESIS OF CALICHEAMICINONE - NEW ARRANGEMENTS FOR ACTUATION OF THE REDUCTIVE CYCLOAROMATIZATION OF AGLYCON CONGENERS [J].
HASELTINE, JN ;
CABAL, MP ;
MANTLO, NB ;
IWASAWA, N ;
YAMASHITA, DS ;
COLEMAN, RS ;
DANISHEFSKY, SJ ;
SCHULTE, GK .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (10) :3850-3866
[3]  
JONES GB, 1994, TETRAHEDRON LETT, V35, P2655
[4]  
JONES GB, Patent No. 5436361
[5]   SYNTHETIC AND MECHANISTIC STUDIES ON ESPERAMICIN-A1 AND CALICHEAMICIN-GAMMA-1 - MOLECULAR STRAIN RATHER THAN PI-BOND PROXIMITY DETERMINES THE CYCLOAROMATIZATION RATES OF BICYCLO[7.3.1] ENEDIYNES [J].
MAGNUS, P ;
FORTT, S ;
PITTERNA, T ;
SNYDER, JP .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) :4986-4987
[6]   CYCLIC CONJUGATED ENEDIYNES RELATED TO CALICHEAMICINS AND ESPERAMICINS - CALCULATIONS, SYNTHESIS, AND PROPERTIES [J].
NICOLAOU, KC ;
ZUCCARELLO, G ;
OGAWA, Y ;
SCHWEIGER, EJ ;
KUMAZAWA, T .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (14) :4866-4868
[7]   CHEMISTRY AND BIOLOGY OF THE ENEDIYNE ANTICANCER ANTIBIOTICS [J].
NICOLAOU, KC ;
DAI, WM .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (11) :1387-1416
[8]   CHEMISTRY AND BIOLOGY OF NATURAL AND DESIGNED ENEDIYNES [J].
NICOLAOU, KC ;
SMITH, AL ;
YUE, EW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :5881-5888
[9]   CYCLOAROMATIZATION OF A 10-MEMBERED ENEDIYNE DERIVATIVE VIA AN ALLENIC SULFONE INTERMEDIATE AND ITS DNA CLEAVING ACTIVITY [J].
SAKAI, Y ;
BANDO, Y ;
SHISHIDO, K ;
SHIBUYA, M .
TETRAHEDRON LETTERS, 1992, 33 (07) :957-960
[10]   THE EFFECT ON DNA CLEAVAGE POTENCY OF TETHERING A SIMPLE CYCLIC ENEDIYNE TO A NETROPSIN ANALOG [J].
SEMMELHACK, MF ;
GALLAGHER, JJ ;
DING, WD ;
KRISHNAMURTHY, G ;
BABINE, R ;
ELLESTAD, GA .
JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (16) :4357-4359