What have we learned from gene targeting studies for the renin angiotensin system of the kidney?

被引：15

作者：

Nishimura, H ^{[1
]}

Ichikawa, I ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

来源：

INTERNAL MEDICINE | 1999年 / 38卷 / 04期

关键词：

gene targeting; kidney regional gene targeting;

D O I：

10.2169/internalmedicine.38.315

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the last decade, gene targeting technologies have provided investigators with powerful new tools to study the physiology and pathophysiology of the kidney. In that, the renin-angiotensin system (RAS) has been a subject of intense investigation. Detailed analyses of mutant mice have not only confirmed notions already suggested by other studies, but also shed a new light on previously unrecognized functions of RAS, In this review we will focus on what we have learned from these gene targeted animals in particular relevance to nephrology.

引用

页码：315 / 323

页数：9

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