Synthesis of magnetic nanoparticles and their application to bioassays

被引：154

作者：

Osaka, T

Matsunaga, T

Nakanishi, T

Arakaki, A

Niwa, D

Iida, H

机构：

[1] Waseda Univ, Inst Biomed Engn, Tokyo 1620041, Japan

[2] Waseda Univ, Dept Appl Chem, Tokyo 1698555, Japan

[3] Tokyo Univ Agr & Technol, Dept Biotechnol, Koganei, Tokyo 1848588, Japan

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2006年 / 384卷 / 03期

关键词：

magnetic nanoparticle; iron oxide; surface modification; biomolecule detection; patterned surface;

D O I：

10.1007/s00216-005-0255-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Magnetic nanoparticles have been attracting much interest as a labeling material in the fields of advanced biological and medical applications such as drug delivery, magnetic resonance imaging, and array-based assaying. In this review, synthesis of iron oxide magnetic nanoparticles via a reverse micelle system and modification of their surface by an organosilane agent are discussed. Furthermore, as a practical biological assay system, the magnetic detection of biomolecular interactions is demonstrated by using the combination of a patterned substrate modified with a self-assembled monolayer and the magnetic nanoparticles.

引用

页码：593 / 600

页数：8

共 71 条

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