In Vivo and In Vitro Antneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives

被引：83

作者：

Akyol, Sumeyya ^{[1
,2
]}

Ozturk, Gulfer ^{[3
]}

Ginis, Zeynep ^{[3
]}

Armutcu, Ferah ^{[4
]}

Yigitoglu, M. Ramazan ^{[4
]}

Akyol, Omer ^{[5
,6
]}

机构：

[1] Turgut Ozal Univ, Vocat Sch Med Sci, Div Med Lab Tech, Ankara, Turkey

[2] Gaziosmanpasa Univ, Fac Med, Dept Biochem, Tokat, Turkey

[3] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Clin Biochem, Ankara, Turkey

[4] Turgut Ozal Univ, Sch Med, Dept Biochem, Ankara, Turkey

[5] Hacettepe Univ, Sch Med, Dept Biochem, Ankara, Turkey

[6] Council Forens Med, Dept Chem, Ankara, Turkey

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2013年 / 65卷 / 04期

关键词：

FACTOR-KAPPA-B; HUMAN BREAST-CANCER; C6; GLIOMA-CELLS; LEUKEMIA HL-60 CELLS; ABERRANT CRYPT FOCI; INTERCELLULAR COMMUNICATION; POLYPHENOLIC COMPOUNDS; OXIDATIVE STRESS; EPITHELIAL-CELLS; RAT COLON;

D O I：

10.1080/01635581.2013.776693

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer prevention and treatment strategies have attracted increasing interest. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, specifically inhibits NF-B at M concentrations and shows ability to stop 5-lipoxygenase-catalyzed oxygenation of linoleic acid and arachidonic acid. Previous studies have demonstrated that CAPE exhibits antioxidant, antiinflammatory, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and, most improtantly, antineoplastic properties. The primary goal of the present review is to summarize and critically evaluate the current knowledge regarding the anticancer effect of CAPE in different cancer types.

引用

页码：515 / 526

页数：12

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