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The mouse: Genetics meets behaviour

被引：126
作者：
Bucan, M
Abel, T
机构：
[1] Univ Penn, Sch Med, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
[4] Univ Penn, Sch Med, Dept Biol, Philadelphia, PA 19104 USA
来源：
NATURE REVIEWS GENETICS | 2002年 / 3卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrg728
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genetic studies in the mouse are important in the elucidation of molecular pathways that underlie behaviour. The advantages of the mouse for behavioural studies include an extensive array of genetic technologies and an elaborate behavioural repertoire that can be used to create models of human disease. This review discusses the relative advantages of forward and reverse genetic approaches to studying the genetic basis of behaviour in the mouse, and the complexities that behavioural studies need to address, such as phenotypic variability, genetic background effects and pleiotropy.
引用
收藏
页码：114 / 123
页数：10
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