Calcium-binding proteins of Entamoeba histolytica

被引：41

作者：

Bhattacharya, A

Padhan, N

Jain, R

Bhattacharya, S

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

[2] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi 110067, India

来源：

ARCHIVES OF MEDICAL RESEARCH | 2006年 / 37卷 / 02期

关键词：

E; histolytica; calcium-binding protein; EF-hand;

D O I：

10.1016/j.arcmed.2005.10.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Calcium plays an essential role in many fundamental processes in almost all eukaryotic cells including protozoan parasite Entamoeba histolytica. Many of the calcium-mediated processes are carried out through the help of calcium-binding proteins (CaBPs). A few of these E. histolytica CaBPs have been described before. These proteins are unique to this organism and are thought to be essential. Availability of genome sequence has opened up the possibility of studying CaBPs at the whole genome level. In this preliminary report, we describe the complement of CaBPs present in E. histolytica. A large fraction of these genes are expressed in the trophozoites and are likely to be functional. The results suggest a number of pathways that are involved in calcium signaling and may be unique for this organism. (C) 2006 IMSS. Published by Elsevier Inc.

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页码：221 / 225

页数：5

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