Porous spherical hydroxyapatite and fluorhydroxyapatite granules: processing and characterization

被引：56

作者：

Komlev, V. S. ^{[1
,2
,3
]}

Barinov, S. M. ^{[1
]}

Girardin, E. ^{[2
,3
]}

Oscarsson, S. ^{[4
]}

Rosengren, A. ^{[4
]}

Rustichelli, F. ^{[2
,3
]}

Orlovskii, V. P. ^{[5
]}

机构：

[1] Russian Acad Sci, Inst Phys Chem Ceram, Ozernaya 48, Moscow 119361, Russia

[2] Univ Ancona, Ist Sci Fis, I-60131 Ancona, Italy

[3] INFM, I-60131 Ancona, Italy

[4] Uppsala Univ, Ctr Surface Biotechnol, S-75123 Uppsala, Sweden

[5] RAS, NS Kurnakov Gen & Inorgan Chem Inst, Moscow 117907, Russia

来源：

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | 2003年 / 4卷 / 06期

关键词：

Hydroxyapatite; Fluorhydroxyapatite; Granules; Protein adsorption;

D O I：

10.1016/j.stam.2003.11.007

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

This study is aimed at the development of a method to fabricate porous spherical hydroxyapatite (HA)-fluorapatite (FA) granules. The method to produce porous granules is based on liquid immiscibility effect. A suspension of HA-FA powder mixtures in aqueous solution of gelatin and oil as a dispersion media were used. By stirring the mixtures of these immiscible liquids, granules of 50-200 mm diameter can easily be produced. The granules were characterized with respect to their microstructure, phase composition and specific area. In vitro testing of human plasma protein adsorption onto the granules of HA and fluorhydroxyapatite were performed. No kind of difference in the dynamic protein adsorption between pure HA and the HA up to 10 wt% FA materials has been revealed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：503 / 508

页数：6

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