MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

被引：678

作者：

Kotlyarov, A

Neininger, A

Schubert, C

Eckert, R

Birchmeier, C

Volk, HD

Gaestel, M

机构：

[1] Univ Halle Wittenberg, Innovat Kolleg Zellspezialisierung, D-06120 Halle, Germany

[2] Humboldt Univ, Inst Med Immunol, D-10098 Berlin, Germany

[3] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1038/10061

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase, By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endotoxic shock. This is due to a reduction of -90 % in the production of tumor necrosis factor-alpha (TNF-alpha) and not to a change in signalling from the TNF receptor. The level and stability of TNF-alpha mRNA is not reduced and TNF-alpha secretion is not affected. We conclude that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-alpha at a post-transcriptional level.

引用

页码：94 / 97

页数：4

共 34 条

[21] MICE LACKING THE TUMOR-NECROSIS-FACTOR RECEPTOR-1 ARE RESISTANT TO TNF-MEDIATED TOXICITY BUT HIGHLY SUSCEPTIBLE TO INFECTION BY LISTERIA-MONOCYTOGENES [J].