MicroRNA precursors in motion: exportin-5 mediates their nuclear export

被引：196

作者：

Kim, VN ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Biol Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2004.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of microRNAs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors - including the identity of the miRNA nuclear export receptor remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-p-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).

引用

页码：156 / 159

页数：4

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