Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents

被引：10

作者：

Nasr, F ^{[1
]}

MacIntyre, E ^{[1
]}

Venuat, AM ^{[1
]}

Bayle, C ^{[1
]}

Carde, P ^{[1
]}

Ribrag, V ^{[1
]}

机构：

[1] INST GUSTAVE ROUSSY,SERV MED C,VILLEJUIF,FRANCE

来源：

LEUKEMIA & LYMPHOMA | 1997年 / 25卷 / 3-4期

关键词：

secondary leukemia; anti-topoisomerase II;

D O I：

10.3109/10428199709114180

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Secondary therapy-related, acute lymphoblastic leukemia (S-ALL) is less common than its myeloblastic counterpart. S-ALL with MLL gene rearrangements have only been reported on six previous occasions. Only three of these had t(4;11)(q21;23) S-ALL with MLL-AF4 fusion transcript has only been reported in one earlier case. In this report a rare case of S-ALL with MLL-AF4 transcript is described in a 36 year old woman treated for breast carcinoma with chemotherapy which included the topoisomerase II inhibitor, VP-16. The precise incidence of MLL gene rearrangement in S-ALL still remains to be clarified.

引用

页码：399 / 401

页数：3

共 9 条

[1] SECONDARY ACUTE LYMPHOBLASTIC-LEUKEMIA WITH T (4-11) - REPORT ON 2 CASES AND REVIEW OF THE LITERATURE [J].