Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations

被引：618

作者：

Brodin, T. ^{[1
]}

Fick, J. ^{[2
]}

Jonsson, M. ^{[1
]}

Klaminder, J. ^{[1
]}

机构：

[1] Umea Univ, Dept Ecol & Environm Sci, S-90187 Umea, Sweden

[2] Umea Univ, Dept Chem, S-90187 Umea, Sweden

来源：

SCIENCE | 2013年 / 339卷 / 6121期

基金：

瑞典研究理事会;

关键词：

RISK TRADE-OFF; ENVIRONMENTAL RISK; PERSONALITY; BOLDNESS; PHARMACEUTICALS; PLASTICITY; PREDATORS; MORTALITY; PRODUCTS; ECOLOGY;

D O I：

10.1126/science.1226850

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Environmental pollution by pharmaceuticals is increasingly recognized as a major threat to aquatic ecosystems worldwide. A variety of pharmaceuticals enter waterways by way of treated wastewater effluents and remain biochemically active in aquatic systems. Several ecotoxicological studies have been done, but generally, little is known about the ecological effects of pharmaceuticals. Here we show that a benzodiazepine anxiolytic drug (oxazepam) alters behavior and feeding rate of wild European perch (Perca fluviatilis) at concentrations encountered in effluent-influenced surface waters. Individuals exposed to water with dilute drug concentrations (1.8 micrograms liter(-1)) exhibited increased activity, reduced sociality, and higher feeding rate. As such, our results show that anxiolytic drugs in surface waters alter animal behaviors that are known to have ecological and evolutionary consequences.

引用

页码：814 / 815

页数：2

共 23 条

[1] Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? [J].

Boxall, Alistair B. A. ;

Rudd, Murray A. ;

Brooks, Bryan W. ;

Caldwell, Daniel J. ;

Choi, Kyungho ;

Hickmann, Silke ;

Innes, Elizabeth ;

Ostapyk, Kim ;

Staveley, Jane P. ;

Verslycke, Tim ;

Ankley, Gerald T. ;

Beazley, Karen F. ;

Belanger, Scott E. ;

Berninger, Jason P. ;

Carriquiriborde, Pedro ;

Coors, Anja ;

DeLeo, Paul C. ;

Dyer, Scott D. ;

Ericson, Jon F. ;

Gagne, Francois ;

Giesy, John P. ;

Gouin, Todd ;

Hallstrom, Lars ;

Karlsson, Maja V. ;

Larsson, D. G. Joakim ;

Lazorchak, James M. ;

Mastrocco, Frank ;

McLaughlin, Alison ;

McMaster, Mark E. ;

Meyerhoff, Roger D. ;

Moore, Roberta ;

Parrott, Joanne L. ;

Snape, Jason R. ;

Murray-Smith, Richard ;

Servos, Mark R. ;

Sibley, Paul K. ;

Straub, Juerg Oliver ;

Szabo, Nora D. ;

Topp, Edward ;

Tetreault, Gerald R. ;

Trudeau, Vance L. ;

Van Der Kraak, Glen .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2012, 120 (09) :1221-1229

[2] Conflicting selection pressures on the growth/predation risk trade-off in a damselfly [J].

Brodin, T ;

Johansson, F .

ECOLOGY, 2004, 85 (11) :2927-2932

[3] Photodegradation of psychiatric pharmaceuticals in aquatic environments - Kinetics and photodegradation products [J].

Calisto, Vania ;

Domingues, M. Rosario M. ;

Esteves, Valdemar I. .

WATER RESEARCH, 2011, 45 (18) :6097-6106

[4] Psychiatric pharmaceuticals in the environment [J].

Calisto, Vania ;

Esteves, Valdemar I. .

CHEMOSPHERE, 2009, 77 (10) :1257-1274

[5] The behavioural ecology of personality: consistent individual differences from an adaptive perspective [J].

Dall, SRX ;

Houston, AI ;

McNamara, JM .

ECOLOGY LETTERS, 2004, 7 (08) :734-739

[6] TENDENCY TO INSPECT PREDATORS PREDICTS MORTALITY RISK IN THE GUPPY (POECILIA-RETICULATA) [J].

DUGATKIN, LA .

BEHAVIORAL ECOLOGY, 1992, 3 (02) :124-127

[7] ENERGETICS OF FEEDING, METABOLISM AND GROWTH OF BROWN TROUT(SALMO-TRUTTA-L) IN RELATION TO BODY-WEIGHT, WATER TEMPERATURE AND RATION SIZE [J].

ELLIOTT, JM .

JOURNAL OF ANIMAL ECOLOGY, 1976, 45 (03) :923-948

[8] Plasticity in animal personality traits: does prior experience alter the degree of boldness? [J].

Frost, Ashley J. ;

Winrow-Giffen, Alexandria ;

Ashley, Paul J. ;

Sneddon, Lynne U. .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2007, 274 (1608) :333-339

[9] Evolutionary conservation of human drug targets in organisms used for environmental risk assessments [J].

Gunnarsson, Lina ;

Jauhiainen, Alexandra ;

Kristiansson, Erik ;

Nerman, Olle ;

Larsson, D. G. Joakim .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (15) :5807-5813

[10] Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry [J].

Hummel, Daniela ;

Loeffler, Dirk ;

Fink, Guido ;

Ternes, Thomas A. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2006, 40 (23) :7321-7328

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