Regulation of T cell development by the deubiquitinating enzyme CYLD

被引：191

作者：

Reiley, WW ^{[1
]}

Zhang, MY ^{[1
]}

Jin, W ^{[1
]}

Losiewicz, M ^{[1
]}

Donohue, KB ^{[1
]}

Norbury, CC ^{[1
]}

Sun, SC ^{[1
]}

机构：

[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 04期

关键词：

D O I：

10.1038/ni1315

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes. CYLD physically interacted with active Lck and promoted recruitment of active Lck to its substrate, Zap70. CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck. Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells.

引用

收藏

页码：411 / 417

页数：7

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