Efficacy of ravuconazole in treatment of systemic murine histoplasmosis

被引：22

作者：

Clemons, KV

Martinez, M

Calderon, L

Stevens, DA

机构：

[1] Santa Clara Valley Med Ctr, Div Infect Dis, Dept Med, San Jose, CA 95128 USA

[2] Santa Clara Valley Med Ctr, Calif Inst Med Res, San Jose, CA 95128 USA

[3] Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期

关键词：

D O I：

10.1128/AAC.46.3.922-924.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis. All regimens tested prolonged survival (P < 0.05 to 0.0001). At equivalent doses of 50 mg/kg of body weight, RCZ and ITZ were equally effective and RCZ was more effective than FCZ (P = 0.02). Clearance of fungal burden from the livers and spleens of mice showed RCZ and ITZ at doses of 50 mg/kg to be efficacious but not curative. These data indicate that RCZ should be studied further.

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页码：922 / 924

页数：3

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