Perhaps one of the most elusive areas of study in autoimmunity has been identifying the self-antigens that initially trigger the development of autoimmune responses. Recent work in this area has demonstrated that a number of biochemical modifications that arise in proteins after their translation induce autoimmune responses to otherwise ignored self-proteins. This article will describe those autoimmune diseases in which posttranslational modifications may play a role in initiation of disease, as well as identify how these modifications arise and contribute to the breakdown of immune tolerance. Lastly, we will address how posttranslational modifications in self-antigens affect current diagnostic techniques and the development of immunotherapies for autoimmune diseases. (C) 2002 Lippincott Williams Wilkins, Inc.
机构:
Technion Israel Inst Technol, Fac Med, Biochem Unit, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Biochem Unit, IL-31096 Haifa, Israel
Hershko, A
Ciechanover, A
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机构:Technion Israel Inst Technol, Fac Med, Biochem Unit, IL-31096 Haifa, Israel
机构:
Technion Israel Inst Technol, Fac Med, Biochem Unit, IL-31096 Haifa, IsraelTechnion Israel Inst Technol, Fac Med, Biochem Unit, IL-31096 Haifa, Israel
Hershko, A
Ciechanover, A
论文数: 0引用数: 0
h-index: 0
机构:Technion Israel Inst Technol, Fac Med, Biochem Unit, IL-31096 Haifa, Israel