Posttranslational protein modifications: new flavors in the menu of autoantigens

被引:65
作者
Doyle, HA [1 ]
Mamula, MJ [1 ]
机构
[1] Yale Univ, Sch Med, Rheumatol Sect, New Haven, CT 06520 USA
关键词
D O I
10.1097/00002281-200205000-00009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Perhaps one of the most elusive areas of study in autoimmunity has been identifying the self-antigens that initially trigger the development of autoimmune responses. Recent work in this area has demonstrated that a number of biochemical modifications that arise in proteins after their translation induce autoimmune responses to otherwise ignored self-proteins. This article will describe those autoimmune diseases in which posttranslational modifications may play a role in initiation of disease, as well as identify how these modifications arise and contribute to the breakdown of immune tolerance. Lastly, we will address how posttranslational modifications in self-antigens affect current diagnostic techniques and the development of immunotherapies for autoimmune diseases. (C) 2002 Lippincott Williams Wilkins, Inc.
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页码:244 / 249
页数:6
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