Synaptic pathology in the brain cortex of old monkeys as an early alteration in senile plaque formation

被引：14

作者：

Bertoni-Freddari, C

Fattoretti, P

Giorgetti, B

Grossi, Y

Balietti, M

Casoli, T

Di Stefano, G

Perretta, G

机构：

[1] INRCA Ancona, Res Dept, Neurobiol & Aging Lab, I-60121 Ancona, Italy

[2] CNR, Ist Neurobiol & Med Mol, Rome, Italy

来源：

REJUVENATION RESEARCH | 2006年 / 9卷 / 01期

关键词：

D O I：

10.1089/rej.2006.9.85

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Synaptic numeric density (Nv), average size (area: S), surface density (Sv) and number of synapses/neurone (Syn/Neur) were morphometrically measured in frontal (FC) and temporal (TC) cortex of adult and old monkeys. Sv was constant, a clear age-related trend to decrease by Nv and increase by S were observed in both areas investigated. Syn/Neur significantly decreased in TC of aged animals (-21.1%), whereas FC showed a not significant reduction (-2.6%). The present data support the hypothesis of an increased sensitivity to deterioration of TC synapses in aged monkeys, which might constitute a predisposing condition to the development of senile plaques.

引用

页码：85 / 88

页数：4