Development of modified Pauson-Khand reactions with ethylene and utilisation in the total synthesis of (+)-taylorione

被引：59

作者：

Donkervoort, JG ^{[1
]}

Gordon, AR ^{[1
]}

Johnstone, C ^{[1
]}

Kerr, WJ ^{[1
]}

Lange, U ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,GLASGOW G1 1XL,LANARK,SCOTLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 21期

关键词：

D O I：

10.1016/0040-4020(96)00259-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two complementary Pauson-Khand annulation protocols for use with the gaseous alkene, ethylene, are described These N-oxide promoted reactions (10 examples) are shown to proceed under both mild autoclave conditions or, more conveniently, at atmospheric pressure. The developed methodology has been utilised as the key transformation in the total synthesis of the sesquiterpene (+)-taylorione which has been realised in a good overall yield from readily available (+)-2-carene. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7391 / 7420

页数：30

共 119 条

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