Liquid chromatography-nuclear magnetic resonance spectroscopy

A general overview of the experimental set-up for performing analytical-scale and nanoliter-scale liquid chromatography-H-1 nuclear magnetic resonance spectroscopy (LC-H-1-NMR) experiments is given. The high power of combining LC with LH-NMR spectroscopy is demonstrated by two examples, where NMW acquisition was performed either in the continuous-flow mode on the analytical scale or in the stopped-flow mode on the nanoliter scale. Current developments employing the on-line coupling of capillary as well as supercritical fluid separation methods with H-1-NMR spectroscopy together with LC-C-13-NMR spectroscopy are discussed. (C) 1999 Elsevier Science B.V. All rights reserved.