Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer

被引：58

作者：

Harris, RE ^{[1
]}

Robertson, FM ^{[1
]}

Abou-Issa, HM ^{[1
]}

Farrar, WB ^{[1
]}

Brueggemeier, R ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

MEDICAL HYPOTHESES | 1999年 / 52卷 / 04期

关键词：

D O I：

10.1054/mehy.1998.0009

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A novel model of mammary carcinogenesis is proposed involving sequential induction and upregulation of cyclooxygenase and aromatase genes by essential fatty acids prominent in the US diet. The basic carcinogenic processes are: (1) constitutive prostaglandin biosynthesis and formation of mutagenic oxygen and nitrogen free radicals responsible for tumor initiation; (2) PGE-2-induced expression of aromatase and constitutive estrogen biosynthesis which sustains mitogenesis and tumor promotion; and (3) PGE-2-induced expression of vascular endothelial growth factor which stimulates angiogenesis and tumor metastasis.

引用

页码：291 / 292

页数：2

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