4D embryonic cardiography using gated optical coherence tomography

被引：88

作者：

Jenkins, MW ^{[1
]}

Rothenberg, F

Roy, D

Nikolski, VP

Hu, Z

Watanabe, M

Wilson, DL

Efimov, IR

Rollins, AM

机构：

[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[2] Duke Univ, Dept Pediat, Durham, NC 27708 USA

[3] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA

[4] Case Western Reserve Univ, Dept Pediat, Cleveland, OH 44106 USA

来源：

OPTICS EXPRESS | 2006年 / 14卷 / 02期

关键词：

D O I：

10.1364/OPEX.14.000736

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Simultaneous imaging of very early embryonic heart structure and function has technical limitations of spatial and temporal resolution. We have developed a gated technique using optical coherence tomography (OCT) that can rapidly image beating embryonic hearts in four-dimensions (4D), at high spatial resolution (10-15 um), and with a depth penetration of 1.5 - 2.0 mm that is suitable for the study of early embryonic hearts. We acquired data from paced, excised, embryonic chicken and mouse hearts using gated sampling and employed image processing techniques to visualize the hearts in 4D and measure physiologic parameters such as cardiac volume, ejection fraction, and wall thickness. This technique is being developed to longitudinally investigate the physiology of intact embryonic hearts and events that lead to congenital heart defects. (c) 2006 Optical Society of America.

引用

页码：736 / 748

页数：13

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