Acellular Biomaterials: An Evolving Alternative to Cell-Based Therapies

被引：123

作者：

Burdick, Jason A. ^{[1
]}

Mauck, Robert L. ^{[1
,2
]}

Gorman, Joseph H., III ^{[3
]}

Gorman, Robert C. ^{[3
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2013年 / 5卷 / 176期

关键词：

HYDROGELS; DELIVERY; REGENERATION; INFARCTION; RELEASE; MATRIX;

D O I：

10.1126/scitranslmed.3003997

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.

引用

页数：4

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