Stem cells and biomimetic materials strategies for tissue engineering

被引：131

作者：

Liao, Susan ^{[2
]}

Chan, Casey K. ^{[2
]}

Ramakrishna, S. ^{[1
,3
]}

机构：

[1] Natl Univ Singapore, Fac Engn, Healthcare & Energy Mat Lab, Div Bioengn,Nanosci & Nanosci & Nanotechnol Initi, Singapore 117576, Singapore

[2] Natl Univ Singapore, Yang Loo Lin Sch Med, Dept Orthopaed Surg, Singapore 119074, Singapore

[3] Natl Univ Singapore, Fac Engn, Dept Mech Engn, Singapore 117576, Singapore

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2008年 / 28卷 / 08期

关键词：

Stem cells; Tissue engineering; Biomimetic materials; Nanotexture; Cell therapy;

D O I：

10.1016/j.msec.2008.08.015

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

Stem cells have been recognized as a promising alternative to somatic cells in the application of cell therapy owing to their potential to renew themselves through cell division and to differentiate into a wide range of specialized cell types. In order to maintain the phenotype expression and differentiated functions of stem cells, the simulated natural environment of the biomimetic material support has to provide the appropriate signals to the attached cells. Scaffolds with biomimetic components and nanotexture can provide chemical, physical as well as spatial cues that are essential to mimic natural tissue growth. Moreover, the plasticity of stem cells provides the basic possibility for multiple-tissue engineering using a certain type of stem cells. Progress in the understanding of self-renewal and directed differentiation of stem cells on biomimetic materials will lead scientists to propose the possibility of cell-based therapies to treat diseases, including the use of stem cells in tissue engineering. In this review paper, we will discuss the current state of the art and future perspectives on stem cells and biomimetic materials strategies for tissue engineering. (C) 2008 Elsevier B.V. All rights reserved

引用

页码：1189 / 1202

页数：14

共 158 条

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Low level laser irradiation stimulates osteogenic phenotype of mesenchymal stem cells seeded on a three-dimensional biomatrix [J].