Glycoprotein Synthesis: An Update

被引:493
作者
Gamblin, David P. [1 ]
Scanlan, Eoin M. [1 ]
Davis, Benjamin G. [1 ]
机构
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
基金
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
NATIVE CHEMICAL LIGATION; SOLID-PHASE SYNTHESIS; BETA-N-ACETYLGLUCOSAMINIDASE; SITE-SPECIFIC GLYCOSYLATION; EXPRESSED PROTEIN LIGATION; S-LINKED GLYCOPEPTIDES; SUGAR-ASSISTED LIGATION; ACID BUILDING-BLOCKS; ENZYMATIC OLIGOSACCHARIDE SYNTHESIS; TRACELESS STAUDINGER LIGATION;
D O I
10.1021/cr078291i
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A review that provides an update on an earlier review on the synthesis of glycoproteins is presented. The review focuses on highlighting key developments in the area from 2002 and provide essential information about the process. It includes specific areas of potential applications of the synthesis process to provide a detailed update. It reveals that carbohydrates continue to play a key role in the synthesis of glycoproteins. Carbohydrates are increasingly being used in synthesizing such proteins, as they are able to modify their other physiochemical properties. The review also reveals that significant developments in glycopeptide or glycoprotein synthesis are increasing the number of potential applications for such proteins. A number of biomedical researchers are developing new drug products, adopting the process of synthesizing glycoproteins.
引用
收藏
页码:131 / 163
页数:33
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