The many roads to cross-presentation

被引：59

作者：

Groothuis, TAM ^{[1
]}

Neefjes, J ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Tumor Biol, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 10期

关键词：

D O I：

10.1084/jem.20051379

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes ( CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.

引用

页码：1313 / 1318

页数：6

共 31 条

[11] ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells [J].

Guermonprez, P ;

Saveanu, L ;

Kleijmeer, M ;

Davoust, J ;

van Endert, P ;

Amigorena, S .

NATURE, 2003, 425 (6956) :397-402

[12] Identification and characterisation of a new human glucose-6-phosphatase isoform [J].

Guionie, O ;

Clottes, E ;

Stafford, K ;

Burchell, A .

FEBS LETTERS, 2003, 551 (1-3) :159-164

[13] Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens [J].

Heath, WR ;

Belz, GT ;

Behrens, GMN ;

Smith, CM ;

Forehan, SP ;

Parish, IA ;

Davey, GM ;

Wilson, NS ;

Carbone, FR ;

Villadangos, JA .

IMMUNOLOGICAL REVIEWS, 2004, 199 (01) :9-26

[14] Phagosomes are competent organelles for antigen cross-presentation [J].

Houde, M ;

Bertholet, S ;

Gagnon, E ;

Brunet, S ;

Goyette, G ;

Laplante, A ;

Princiotta, MF ;

Thibault, P ;

Sacks, D ;

Desjardins, M .

NATURE, 2003, 425 (6956) :402-406

[15] In vivo cross-priming of MHC class I - Restricted antigens requires the TAP transporter [J].

Huang, AYC ;

Bruce, AT ;

Pardoll, DM ;

Levitsky, HI .

IMMUNITY, 1996, 4 (04) :349-355

[16] The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells [J].

Kimachi, K ;

Croft, M ;

Grey, HM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) :3310-3317

[17] Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells [J].

Kurts, C ;

Kosaka, H ;

Carbone, FR ;

Miller, JFAP ;

Heath, WR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (02) :239-245

[18] Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain [J].

Lizée, G ;

Basha, G ;

Tiong, J ;

Julien, JP ;

Tian, MM ;

Biron, KE ;

Jefferies, WA .

NATURE IMMUNOLOGY, 2003, 4 (11) :1065-1073

[19] FOLDING AND ASSEMBLY OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I HETERODIMERS IN THE ENDOPLASMIC-RETICULUM OF INTACT-CELLS PRECEDES THE BINDING OF PEPTIDE [J].

NEEFJES, JJ ;

HAMMERLING, GJ ;

MOMBURG, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :1971-1980

[20] Cross-presentation by intercellular peptide transfer through gap junctions [J].

Neijssen, J ;

Herberts, C ;

Drijfhout, JW ;

Reits, E ;

Janssen, L ;

Neefjes, J .

NATURE, 2005, 434 (7029) :83-88

← 1 2 3 4 →