Time-Dependent Processes in Stem Cell-Based Tissue Engineering of Articular Cartilage

被引：79

作者：

Gadjanski, Ivana ^{[2
]}

Spiller, Kara

Vunjak-Novakovic, Gordana ^{[1
]}

机构：

[1] Columbia Univ, Dept Biomed Engn, Lab Stem Cells & Tissue Engn, New York, NY 10032 USA

[2] Metropolitan Univ Belgrade, R&D Ctr Bioengn, Kragujevac 34000, Serbia

来源：

STEM CELL REVIEWS AND REPORTS | 2012年 / 8卷 / 03期

关键词：

Cartilage tissue engineering; Mesenchymal stem cells; Embryonic stem cells; Induced pluripotent stem cells; MESENCHYMAL PROGENITOR CELLS; HYALURONIC-ACID HYDROGELS; CHONDROGENIC DIFFERENTIATION; BONE-MARROW; IN-VITRO; MECHANICAL COMPRESSION; DYNAMIC COMPRESSION; SYNOVIAL JOINT; CHONDROCYTE DIFFERENTIATION; NEOCARTILAGE FORMATION;

D O I：

10.1007/s12015-011-9328-5

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Articular cartilage (AC), situated in diarthrodial joints at the end of the long bones, is composed of a single cell type (chondrocytes) embedded in dense extracellular matrix comprised of collagens and proteoglycans. AC is avascular and alymphatic and is not innervated. At first glance, such a seemingly simple tissue appears to be an easy target for the rapidly developing field of tissue engineering. However, cartilage engineering has proven to be very challenging. We focus on time-dependent processes associated with the development of native cartilage starting from stem cells, and the modalities for utilizing these processes for tissue engineering of articular cartilage.

引用

页码：863 / 881

页数：19

共 193 条

[1]

The transcrintion factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 [J].