Nickel(II)-catalyzed Michael additions.: Formation of quaternary centers and diastereoselective addition of enantiopure N-acetoacetyl-4-benzyloxazolidin-2-one

被引：53

作者：

Clariana, J

Gálvez, N

Marchi, C

Mañas, MM ^{[1
]}

Vallribera, A

Molins, E

机构：

[1] Univ Autonoma Barcelona, Dept Chem, E-08193 Barcelona, Spain

[2] CSIC, Inst Ciencia Mat Barcelona, E-08193 Cerdanyola, Spain

来源：

TETRAHEDRON | 1999年 / 55卷 / 23期

关键词：

nickel catalysis; conjugate addition; quaternary centers; chiral induction; amides of malonic acid;

D O I：

10.1016/S0040-4020(99)00358-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ni(acac)(2) and Ni(salicylaldehydate)(2) are effective catalysts for conjugate additions of 2-methyl-1,3-dicarbonyl compounds to Michael accepters, Significant diastereomeric excesses are obtained in the Michael additions of enantiopure N-acetoacetyl-4-benzyloxazolidinones. Reaction of the latter compound with aryl isocyanates affords unsymmetrical diamides of malonic acid, (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7331 / 7344

页数：14