Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

被引:25
作者
Mueller, Sebastian [1 ]
Pantos, G. Dan [1 ]
Rodriguez, Raphael [1 ]
Balasubramanian, Shankar [1 ]
机构
[1] Univ Cambridge, Univ Chem Lab, Cambridge CB2 1EW, England
关键词
C-KIT ONCOGENE; BINDING LIGANDS; TRANSCRIPTION; MACROCYCLES; DERIVATIVES; INHIBITION; TELOMERASE; PORPHYRIN; PROMOTER; MYC;
D O I
10.1039/b816861j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Differential recognition of diverse G-quadruplex structures can be achieved by controlling the folding of a small molecule.
引用
收藏
页码:80 / 82
页数:3
相关论文
共 22 条
[1]   Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression [J].
Bejugam, Mallesham ;
Sewitz, Sven ;
Shirude, Pravin S. ;
Rodriguez, Raphael ;
Shahid, Ramla ;
Balasubramanian, Shankar .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (43) :12926-+
[2]  
Berl V, 2001, CHEM-EUR J, V7, P2810, DOI 10.1002/1521-3765(20010702)7:13<2810::AID-CHEM2810>3.0.CO
[3]  
2-5
[4]   Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry [J].
Bugaut, Anthony ;
Jantos, Katja ;
Wietor, Jean-Luc ;
Rodriguez, Raphael ;
Sanders, Jeremy K. M. ;
Balasubramanian, Shankar .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (14) :2677-2680
[5]   G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription [J].
Cogoi, Susanna ;
Xodo, Luigi E. .
NUCLEIC ACIDS RESEARCH, 2006, 34 (09) :2536-2549
[6]   A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene [J].
Fernando, Himesh ;
Reszka, Anthony P. ;
Huppert, Julian ;
Ladame, Sylvain ;
Rankin, Sarah ;
Venkitaraman, Ashok R. ;
Neidle, Stephen ;
Balasubramanian, Shankar .
BIOCHEMISTRY, 2006, 45 (25) :7854-7860
[7]   The G-quadruplex ligand telomestatin inhibits POT1 binding to Telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells [J].
Gomez, Dennis ;
O'Donohue, Marie-Francoise ;
Wenner, Thomas ;
Douarre, Cine ;
Macadre, Jerome ;
Koebel, Pascale ;
Giraud-Panis, Marie-Josephe ;
Kaplan, Herve ;
Kolkes, Alain ;
Shin-ya, Kazuo ;
Riou, Jean-Francois .
CANCER RESEARCH, 2006, 66 (14) :6908-6912
[8]   Oxazole-based peptide macrocycles: A new class of G-quadruplex binding ligands [J].
Jantos, Katja ;
Rodriguez, Raphael ;
Ladame, Sylvain ;
Shirude, Pravin S. ;
Balasubramanian, Shankar .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (42) :13662-13663
[9]   Aromatic δ-peptides [J].
Jiang, H ;
Léger, JM ;
Huc, I .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (12) :3448-3449
[10]  
Mergny JL, 2001, CHEMBIOCHEM, V2, P124, DOI 10.1002/1439-7633(20010202)2:2<124::AID-CBIC124>3.0.CO