Differentiation of progenitors in the liver: a matter of local choice

被引：99

作者：

Boulter, Luke ^{[1
]}

Lu, Wei-Yu ^{[1
]}

Forbes, Stuart J. ^{[1
]}

机构：

[1] Univ Edinburgh, MRC, Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2013年 / 123卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

HEPATIC STELLATE-CELLS; INTRAHEPATIC BILE-DUCTS; GENE-EXPRESSION PROFILE; EPIDERMAL STEM-CELLS; BETA-CATENIN; ALAGILLE-SYNDROME; STEM/PROGENITOR CELLS; DUCTULAR REACTIONS; STREAMING LIVER; BILIARY TREE;

D O I：

10.1172/JCI66026

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.

引用

页码：1867 / 1873

页数：7

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