Use of ultra-performance liquid chromatography in pharmaceutical development

被引：199

作者：

Wren, Stephen A. C. ^{[1
]}

Tchelitcheff, Pierre ^{[1
]}

机构：

[1] AstraZeneca, PAR&D, Analy Dev, Macclesfield SK10 2NA, Cheshire, England

来源：

JOURNAL OF CHROMATOGRAPHY A | 2006年 / 1119卷 / 1-2期

关键词：

UPLC; ultra performance liquid chromatography; pharmaceutical development; PEAK-CAPACITY; PARTICLES; HPLC;

D O I：

10.1016/j.chroma.2006.02.052

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Ultra-perfortriance liquid chromatography (UPLC) has been investigated as an alternative to HPLC for the analysis of pharmaceutical development compounds. We present data on three compounds showing that significant reductions in separation time can be achieved without compromising the separation quality. Results from precision and comparative studies indicate that UPLC is a suitable technique for routine pharmaceutical analysis. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：140 / 146

页数：7

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