Highly enantioselective hydrogenation of α-dehydroamino acids by rhodium complex with H8-MonoPhos

被引：64

作者：

Zeng, Q

Liu, H

Cui, X

Mi, AQ

Jiang, YZ ^{[1
]}

Li, XS

Choi, MCK

Chan, ASC

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Union Lab Asymmetr Synth, Chengdu 610041, Peoples R China

[2] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 02期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(02)00096-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

H-8-MonoPhos, a new stable and easily prepared monodentate phosphoramidite ligand, has been synthesized from H-8-BINOL. The ligand showed extremely highly enantioselectivity of higher than 99.9% e.e. in the asymmetric Rh-catalyzed hydrogenation of alpha-dehydroamino acids. Our study further supports the new concept that there is no gap in efficiency and enantioselectivity between monodentate and chelating ligands for asymmetric catalysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：115 / 117

页数：3

共 14 条

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