Leptin and renal disease

被引：47

作者：

Briley, LP ^{[1
]}

Szczech, LA ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Duke Clin Res Inst, Dept Internal Med,Div Nephrol, Durham, NC 27710 USA

来源：

SEMINARS IN DIALYSIS | 2006年 / 19卷 / 01期

基金：

美国国家卫生研究院; 新加坡国家研究基金会;

关键词：

D O I：

10.1111/j.1525-139X.2006.00119.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Leptin is a mediator of metabolism and disease in a variety of organ systemsmost notably as an agent of energy stores. Howeverits role in renal disease as an inflammatory agent as well as its potential impact on the cachexia of uremia have sparked new interest in the molecule for nephrologists. This review elucidates the complex uremic statethe historical discovery of leptin and its physiologyand the potential interactions leptin has on both the progression of kidney disease as well as the morbidity and mortality of end-stage renal disease.

引用

页码：54 / 59

页数：6

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