Proportionate Reduction in Uncertainty of Late Onset Infection in Pre-term Infants by Neutrophil CD64 Measurement

被引：5

作者：

Berrington, Janet Elizabeth ^{[1
]}

Hearn, Richard Iain ^{[2
]}

Hall, Chris ^{[3
]}

Stewart, Christopher James ^{[4
]}

Cummings, Stephen Paul ^{[4
]}

Embleton, Nicholas David ^{[1
]}

机构：

[1] Royal Victoria Infirm, Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Neonatal Serv, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[2] Univ Dundee, Ninewells Hosp & Med Sch, Neonatal Unit, Dundee DD1 9SY, Scotland

[3] Newcastle Upon Tyne Hosp NHS Fdn Trust, Dept Haematol, Newcastle Upon Tyne, Tyne & Wear, England

[4] Northumbria Univ, Fac Hlth & Life Sci, Newcastle Upon Tyne NE1 8ST, Tyne & Wear, England

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2014年 / 33卷 / 01期

关键词：

CD64; pre-term infant; infection; CRP; procalcitonin; DIAGNOSTIC MARKERS; SEPSIS; TESTS;

D O I：

10.3109/15513815.2013.842270

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: Establish howneutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT). Methods: A total of 38preterm infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curveswere generated for CD64 counts at various threshold values. Results: PRU curves reduced the residual uncertainty of the presence of infection by up to 64%. Conclusions: The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.

引用

页码：16 / 22

页数：7

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