Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer

被引：214

作者：

Chaneton, Barbara ^{[1
]}

Gottlieb, Eyal ^{[1
]}

机构：

[1] Canc Res UK, Beatson Inst Canc Res, Glasgow, Lanark, Scotland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2012年 / 37卷 / 08期

关键词：

cancer; pyruvate kinase; PKM2; cancer metabolism; cancer therapeutics; PYRUVATE-KINASE M2; TUMOR-GROWTH; NUCLEAR TRANSLOCATION; MULTIMOLECULAR FORMS; BINDING PROTEIN; E7; ONCOPROTEIN; MESSENGER-RNA; TU M2-PK; EXPRESSION; ISOFORM;

D O I：

10.1016/j.tibs.2012.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer cell metabolism is exemplified by high glucose consumption and lactate production. Pyruvate kinase (PK), which catalyzes the final step of glycolysis, has emerged as a potential regulator of this metabolic phenotype. The M2 isoform of PK (PKM2) is highly expressed in cancer cells. However, the mechanisms by which PKM2 coordinates high energy requirements with high anabolic activities to support cancer cell proliferation are still not completely understood. Current research has elucidated novel regulatory mechanisms for PKM2, contributing to its important role in cancer. This review summarizes the current understanding and explores future directions in the field, highlighting controversies regarding the activity and specificity of PKM2 in cancer. In light of this knowledge, the potential therapeutic implications and strategies are critically discussed.

引用

页码：309 / 316

页数：8

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