Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling

被引：38

作者：

Bibeau-Poirier, Annie

Servant, Marc J. ^{[1
]}

机构：

[1] Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada

来源：

CYTOKINE | 2008年 / 43卷 / 03期

基金：

加拿大健康研究院;

关键词：

Ubiquitination; Phosphorylation; Interferon; Pattern-recognition receptors; Innate immunity;

D O I：

10.1016/j.cyto.2008.07.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational protein modifications are involved in all functions of living cells. This includes the ability of cells to recognize pathogens and regulate genes involved in their clearance, a concept known as innate immunity. While phosphorylation mechanisms play essential roles in regulating different aspects of the innate immune response, ubiquitination is now recognized as another post-translational modification that works in parallel with phosphorylation to orchestrate the final proper innate immune response against invading pathogens. More precisely, this review will discuss the most recent advances that address the role of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：359 / 367

页数：9

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