The SCF ubiquitin ligase: Insights into a molecular machine

被引：976

作者：

Cardozo, T

Pagano, M

机构：

[1] NYU, Med Ctr, Dept Pathol, New York, NY 10016 USA

[2] NYU, Med Ctr, Inst Canc, New York, NY 10016 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1471

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Ubiquitin ligases are well suited to regulate molecular networks that operate on a post-translational timescale. The F-box family of proteins-which are the substrate-recognition components of the Skp1-Cul1-F-box- protein (SCF) ubiquitin ligase-are important players in many mammalian functions. Here we explore a unifying and structurally detailed view of SCF-mediated proteolytic control of cellular processes that has been revealed by recent studies.

引用

收藏

页码：739 / 751

页数：13

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