Kip1 meets SKP2: new links in cell-cycle control

被引：51

作者：

Amati, B ^{[1
]}

Vlach, J ^{[1
]}

机构：

[1] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 04期

关键词：

D O I：

10.1038/12087

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cyclin-dependent kinase inhibitor p27(Kip1) degraded in a phosphorylation- and ubiquitin-dependent way upon cell-cycle entry. p45(SKP2), the adaptor subunit of the ubiquitin-protein ligase SCFSKP2, may mediate recognition and ubiquitination or phosphorylated p27(Kip1).

引用

页码：E91 / E93

页数：3

共 14 条

[1] Amati Bruno, 1998, Frontiers in Bioscience, V3, pD250
[2] SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Carrano, AC
Eytan, E
Hershko, A
Pagano, M
[J]. NATURE CELL BIOLOGY, 1999, 1 (04) : 193 - 199
[3] New insights into the tumor suppression function of P27Kip1
Clurman, BE
Porter, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) : 15158 - 15160
[4] The regulation of E2F by pRB-family proteins
Dyson, N
[J]. GENES & DEVELOPMENT, 1998, 12 (15) : 2245 - 2262
[5] Skipping into the E2F1-destruction pathway
Harper, JW
Elledge, SJ
[J]. NATURE CELL BIOLOGY, 1999, 1 (01) : E5 - E7
[6] How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
Koepp, DM
Harper, JW
Elledge, SJ
[J]. CELL, 1999, 97 (04) : 431 - 434
[7] Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2:: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
Lisztwan, J
Marti, A
Sutterlüty, H
Gstaiger, M
Wirbelauer, C
Krek, W
[J]. EMBO JOURNAL, 1998, 17 (02) : 368 - 383
[8] Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
Marti, A
Wirbelauer, C
Scheffner, M
Krek, W
[J]. NATURE CELL BIOLOGY, 1999, 1 (01) : 14 - 19
[9] CDK inhibitors:: positive and negative regulators of G1-phase progression
Sherr, CJ
Roberts, JM
[J]. GENES & DEVELOPMENT, 1999, 13 (12) : 1501 - 1512
[10] p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
Sutterlüty, H
Chatelain, E
Marti, A
Wirbelauer, C
Senften, M
Müller, U
Krek, W
[J]. NATURE CELL BIOLOGY, 1999, 1 (04) : 207 - 214

← 1 2 →