Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation

被引：21

作者：

Takenawa, T ^{[1
]}

Itoh, T ^{[1
]}

Fukami, K ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Biochem, Minato Ku, Tokyo, Japan

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1999年 / 98卷 / 1-2期

关键词：

phosphatidylinositol 4,5-bisphosphate; phosphatidylinositol monophosphate kinase; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; actin filament reorganization; malignant transformation;

D O I：

10.1016/S0009-3084(99)00014-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well known that phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) plays important roles not only as a precursor lipid for generating second messengers but also as a regulator of cytoskeletal re-organization. The last step of PtdIns(4,5)P2 synthesis is catalyzed by PtdIns monophosphate(PIP) kinase. So far, three type I PIP kinases(alpha, beta, and gamma), which phosphorylate PtdIns(4) to PtdIns(4,5)P2, and three type II PIP kinases(alpha, beta, gamma), which phosphorylate PtdIns(5)P to PtdIns(4,5)P2 have been found. On the other hand, several inositolpolyphosphate 5-phosphatases which convert PtdIns(4,5)P2 to PtdIns(4) are known. Among them, synaptojanin, which associates with tyrosine kinase receptors through an adaptor protein, Ash/Grb2, in response to growth factors, is capable of hydrolyzing PtdIns(4,5)P2 bound to actin regulatory proteins, resulting in actin filament re-organization downstream of tyrosine kinases. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 22

页数：10

共 68 条

[1] THE LOWE OCULOCEREBRORENAL SYNDROME GENE ENCODES A PROTEIN HIGHLY HOMOLOGOUS TO INOSITOL POLYPHOSPHATE-5-PHOSPHATASE [J].

ATTREE, O ;

OLIVOS, IM ;

OKABE, I ;

BAILEY, LC ;

NELSON, DL ;

LEWIS, RA ;

MCINNES, RR ;

NUSSBAUM, RL .

NATURE, 1992, 358 (6383) :239-242

[2] INOSITOL PHOSPHATES AND CELL SIGNALING [J].

BERRIDGE, MJ ;

IRVINE, RF .

NATURE, 1989, 341 (6239) :197-205

[3] THE SEQUENCE OF PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE DEFINES A NOVEL FAMILY OF LIPID KINASES [J].

BORONENKOV, IV ;

ANDERSON, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) :2881-2884

[4] The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4-phosphate 5-kinase [J].

Carvajal, JJ ;

Pook, MA ;

dosSantos, M ;

Doudney, K ;

Hillermann, R ;

Minogue, S ;

Williamson, R ;

Hsuan, JJ ;

Chamberlain, S .

NATURE GENETICS, 1996, 14 (02) :157-162

[5] A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase [J].

Castellino, AM ;

Parker, GJ ;

Boronenkov, IV ;

Anderson, RA ;

Chao, MV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (09) :5861-5870

[6] INTERACTION OF PROTEIN-KINASE-C WITH PHOSPHOINOSITIDES [J].

CHAUHAN, A ;

BROCKERHOFF, H ;

WISNIEWSKI, HM ;

CHAUHAN, VPS .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 287 (02) :283-287

[7] MUTATIONS IN THE SAC1 GENE SUPPRESS DEFECTS IN YEAST GOLGI AND YEAST ACTIN FUNCTION [J].

CLEVES, AE ;

NOVICK, PJ ;

BANKAITIS, VA .

JOURNAL OF CELL BIOLOGY, 1989, 109 (06) :2939-2950

[8]

CONNOLLY TM, 1986, J BIOL CHEM, V261, P122

[9] PROTEIN-KINASE-C PHOSPHORYLATES HUMAN-PLATELET INOSITOL TRISPHOSPHATE 5'-PHOSPHOMONOESTERASE, INCREASING THE PHOSPHATASE-ACTIVITY [J].

CONNOLLY, TM ;

LAWING, WJ ;

MAJERUS, PW .

CELL, 1986, 46 (06) :951-958

[10] Signal transduction - Lipid-regulated kinases: Some common themes at last [J].

Downward, J .

SCIENCE, 1998, 279 (5351) :673-674

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