Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation

被引：21

作者：

Takenawa, T ^{[1
]}

Itoh, T ^{[1
]}

Fukami, K ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Biochem, Minato Ku, Tokyo, Japan

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1999年 / 98卷 / 1-2期

关键词：

phosphatidylinositol 4,5-bisphosphate; phosphatidylinositol monophosphate kinase; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; actin filament reorganization; malignant transformation;

D O I：

10.1016/S0009-3084(99)00014-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is well known that phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) plays important roles not only as a precursor lipid for generating second messengers but also as a regulator of cytoskeletal re-organization. The last step of PtdIns(4,5)P2 synthesis is catalyzed by PtdIns monophosphate(PIP) kinase. So far, three type I PIP kinases(alpha, beta, and gamma), which phosphorylate PtdIns(4) to PtdIns(4,5)P2, and three type II PIP kinases(alpha, beta, gamma), which phosphorylate PtdIns(5)P to PtdIns(4,5)P2 have been found. On the other hand, several inositolpolyphosphate 5-phosphatases which convert PtdIns(4,5)P2 to PtdIns(4) are known. Among them, synaptojanin, which associates with tyrosine kinase receptors through an adaptor protein, Ash/Grb2, in response to growth factors, is capable of hydrolyzing PtdIns(4,5)P2 bound to actin regulatory proteins, resulting in actin filament re-organization downstream of tyrosine kinases. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：13 / 22

页数：10

共 68 条

[41]

MIKI H, 1994, J BIOL CHEM, V269, P5489

[42] N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases [J].

Miki, H ;

Miura, K ;

Takenawa, T .

EMBO JOURNAL, 1996, 15 (19) :5326-5335

[43]

MITCHELL CA, 1989, J BIOL CHEM, V264, P8873

[44] Interaction of Ash/Grb-2 via its SH3 domains with neuron-specific p150 and p65 [J].

Miura, K ;

Miki, H ;

Shimazaki, K ;

Kawai, N ;

Takenawa, T .

BIOCHEMICAL JOURNAL, 1996, 316 :639-645

[45]

MUELLAUER L, 1993, ONCOGENE, V8, P2531

[46] Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern [J].

Nemoto, Y ;

Arribas, M ;

Haffner, C ;

DeCamilli, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :30817-30821

[47] THE ROLE OF PROTEIN KINASE-C IN CELL-SURFACE SIGNAL TRANSDUCTION AND TUMOR PROMOTION [J].

NISHIZUKA, Y .

NATURE, 1984, 308 (5961) :693-698

[48]

PALMER FBS, 1994, J BIOL CHEM, V269, P3403

[49]

PARASAD GR, 1993, P NATL ACAD SCI USA, V90, P7039

[50] AN ESSENTIAL ROLE FOR RAC IN RAS TRANSFORMATION [J].

QIU, RG ;

CHEN, J ;

KIRN, D ;

MCCORMICK, F ;

SYMONS, M .

NATURE, 1995, 374 (6521) :457-459

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